Thus, the metabolite is responsible for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly within the feces (about eighty% of administered oral dose) also to a lesser extent from the urine (close to thirteen% of the administered oral dose). If taken having a high-Excess fat food, absorption is lessened; the time taken to succeed in the utmost plasma focus improves by all-around one hour, and the most concentration alone is diminished by approximately one-3rd.[fifty two]
Immediately after either oral or intravenous administration, sildenafil is excreted as metabolites predominantly within the feces (close to 80% of administered oral dose) and also to a lesser extent in the urine (about thirteen% from the administered oral dose).
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†Abnormal Vision: Delicate to moderate in severity and transient, predominantly coloration tinge to vision, but additionally greater sensitivity to light-weight, or blurred vision.
According to its acknowledged effects around the nitric oxide/cGMP pathway [see Scientific PHARMACOLOGY], VIAGRA was proven to potentiate the hypotensive results of nitrates, and its administration to people who are using nitric oxide donors such as natural and organic nitrates or organic and natural nitrites in almost any form both consistently and/or intermittently is consequently contraindicated.
The imply profiles with the transform from baseline in standing systolic blood pressure in topics taken care of with doxazosin together with 100 mg VIAGRA or matching placebo are demonstrated in Determine 4.
Even though less common, the most significant Unwanted side effects of sildenafil are described under, coupled with what to do whenever they come about.
VIAGRA won't guard you or your companion from receiving sexually transmitted disorders, which include HIV—the virus that causes AIDS.
The following activities happened in < 2% of clients in controlled scientific trials; a causal connection to VIAGRA is unsure. Reported activities incorporate Individuals with a plausible relation to drug use; omitted are minor events and stories much too imprecise to be meaningful:
VIAGRA is just not indicated to be used in Girls. There aren't any ample and well-managed check here scientific studies of sildenafil in Expecting Females.
This doc won't include all doable Uncomfortable side effects and Other individuals may well manifest. Check with the health practitioner For added information regarding Unintended effects.
Nosebleeds. Sildenafil may perhaps result in nosebleeds. You may well be at greater chance for this if you are taking a blood thinner drugs. Inform your healthcare company if you can get nosebleeds frequently even though getting sildenafil. If the nosebleed is intense or won't quit following applying pressure, get assistance at once.
At doses above the suggested dose variety, adverse reactions have been much like These comprehensive in Desk one beneath but usually were claimed additional usually.
Doctors need to examine with individuals the contraindication of VIAGRA with normal and/or intermittent use of nitric oxide donors, like organic nitrates or natural and organic nitrites in almost any type [see CONTRAINDICATIONS].